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In patients taking Zocor concomitantly with fibrates, other than gemfibrozil (see section 4. Tevens zijn bloedvaten onderhuids zeer zichtbaar geworden (blauw/paars)Bij onderzoek in ziekenhuis naar met name lymfe afvoer uit been is niets bijzonders. Simvastatine verlaagt het cholesterol en daardoor ook het vetgehalte in het bloed. Elke 40 mg-tablet bevat 283,0 mg lactosemonohydraat. Er is dan spierpijn die zich met name concentreert in de kuiten en onderrug. Elke 40 mg-tablet bevat 40 mg simvastatine. , Shotton Lane Cramlington, Northumberland NE23 3JU, Verenigd Koninkrijk Schering-Plough Labo NV Industriepark 30 Heist-op-den-Berg, 2220, België Nummers van de vergunning voor het in de handel brengen: Zocor 20 mg: BE147235 Zocor 40 mg: BE190206. Bij patiënten die ZOCOR samen met fibraten, uitgezonderd gemfibrozil (zie rubriek 4. 40mg Merck Sharp & Dohme BV Waarderweg 39 2031 BN Haarlem Nederland Merck, Sharp & Dohme Ltd. Het doseringsbereik is 5 - 80 mg/dag, oraal als eenmalige dosis 's avonds ZOCOR is effectief alleen of in combinatie met galzuurbindende harsen. 40-mg filmomhulde tabletten zijn ovaal van vorm, steenrood, met aan een kant de code "MSD 749" en niets aan de andere kant. Bij combinatie met een galzuurbindend. Bij kinderen (10-17 jaar) is de gebruikelijke aanbevolen startdosering 10 mg eenmaal daags, in de avond in te nemen. Toediening moet hetzij > 2 uur voor of > 4 uur na toediening van een galzuurbindende hars plaatsvinden. Na vier tot zes weken is het volledige effect van dit medicijn bereikt De meeste gehoorde klacht onder simvastatine gebruikers is spierpijn. Bij gelijktijdig gebruik van rifampicine (een sterke CYP3A4–inductor) kan de effectiviteit van simvastatine sterk verminderd zijn. De dosering is 1 tablet Zocor van 10 mg, 20 mg, 40 mg of (ook in de handel zijnde) 80 mg eenmaal daags via de mond (oraal) in te nemen. Mensen die met dit medicijn hun te hoge cholesterolgehalte hebben verlaagd, blijken minder hart- en vaatziekten, zoals hartinfarcten of beroerten te krijgen. Zocor verhoogt de concentratie van het ‘goede’ cholesterol (HDL-cholesterol) Sinds circa 10 jaren gebruik ik Zocor, waarvan de laatste 4 jaren in de dosis van 40mg. Er kan dan ook sprake zijn van spierzwakte, koorts, misselijkheid en braken Simvastatine is een substraat voor OATP1B1; combinatie met remmers van OATP1B1 (zoals ciclosporine) veroorzaken een hogere simvastatinezuurspiegel en meer kans op myopathie. 3) of fenofibraat gebruiken, mag de dosis ZOCOR niet hoger zijn dan 10 mg/dag Zocor is effective alone or in combination with bile acid sequestrants. Zocor is een geneesmiddel voor verlaging van de concentraties in het bloed van het totaalcholesterol, het ‘slechte’ cholesterol (LDL-cholesterol) en vettige stoffen die triglyceriden worden genoemd. Dosing should occur either > 2 hours before or > 4 hours after administration of a bile acid sequestrant. In zeldzame gevallen is dit een bijwerking op de spieren. Sedert die tijd heb ik last van jeuk van de huid aan beide (onder)benen en tevens vochtophoping in de benen met name rond de enkels en voeten. 3) or fenofibrate, the dose of Zocor should not exceed 10 mg/day Werking. De maximale aanbevolen dosering is 40 mg eenmaal daags Zocor bevat de werkzame stof simvastatine.

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