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For angina the usual dose is 80 mg to 120 mg three times a day Both verapamil SR and verapamil IR prolonged the PR interval of the ECG. 1%) therapy was discontinued prematurely, in 139 (3. 3 mg/kg (usual single dose range: 2 to 5 mg) IV bolus over at least 2 minutes. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. The incidence of side effects (headache, palpitations, dizziness and flushing) was dose dependent, decreased with continuous treatment and was much higher with verapamil IR than with verapamil SR.. Children Both verapamil SR and verapamil IR prolonged the PR interval of the ECG. The sustained release (SR) form of this medication is used for the treatment of mild-to-moderate high blood pressure, when beta-blockers or diuretics (water pills) are not recommended or have caused unacceptable side effects In an open multicenter trial (uncontrolled study) in 4,247 patients (49. 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